Twenty years ago the Dalai Lama challenged a select group of world-renowned neuroscientists to look into the workings of the mind, and to prove scientifically that Tibetan Buddhist practices for overcoming negative emotions are skills that can be learned by anyone. His urgency and dedication come through in the documentary as he now turns 82. He must deal with the questions of aging and death, and whether he will reincarnate as the 15th Dalai Lama, or if he will be the last of a lineage that has existed for a millennia.